Tolerance to glyceryl trinitrate patches: prevention by intermittent dosing.

Avoidance of tolerance and lack of rebound with intermittent dose titrated transdermal glyceryl trinitrate.

OBJECTIVES To investigate the efficacy of transdermal glyceryl trinitrate given continuously and with a nocturnal nitrate free period. DESIGN Double blind placebo controlled study with two parallel limbs. SETTING Multicentre trial. PATIENTS 52 patients randomised to receive either continuous treatment (23 patients) or intermittent treatment with an individually titrated dose (29 patients)...

Activation of trigeminovascular neurons by glyceryl trinitrate.

The effect of intra-carotid arterial infusions of glyceryl trinitrate (GTN), a substance known to precipitate headache, including migraine, upon the spontaneous activity of trigeminal neurons with craniovascular input was studied in cats. Second-order craniovascular neurons which received sensory input from the superior sagittal sinus were recorded in the trigeminal nucleus caudalis. Infusions ...

Comparison with glyceryl trinitrate

The coronary haemodynamic effects of nifedipine and glyceryl trinitrate were compared in 22 patients undergoing investigations for suspected coronary artery disease. Myocardial blood flow was estimated by the coronary sinus thermodilution technique. In sinus rhythm nifedipine increased mean coronary sinus flow from 135 ml/min to 152 m/min, and reduced arterio-coronary sinus oxygen difference fr...

Randomized clinical trial of the use of glyceryl trinitrate patches to aid arteriovenous fistula maturation.

BACKGROUND Arteriovenous fistulas are critical for haemodialysis, but maturation rates remain poor. Experimental and anecdotal evidence has supported the use of transdermal glyceryl trinitrate (GTN) patches. The aim of this RCT was to determine whether use of a GTN patch aids arteriovenous fistula maturation. METHODS Patients referred for arteriovenous fistula formation were eligible. The GTN...

Glyceryl trinitrate before coronary angiography.